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Diazepam and its metabolites are excreted predominantly within the urine. Diazepam accumulates upon a number of dosing; consequently, the terminal elimination 50 percent-life of diazepam is marginally extended.

Individuals with Renal impairment: Clinicians should really work out caution when prescribing diazepam to your older populace as they tend to acquire decreased renal operate and clearance; as a result, this inhabitants is at an increased chance of diazepam accumulation and its key metabolites. The advice is to limit the dosage into the smallest efficient volume.

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